American Board of Family Medicine (ABFM) Practice Exam

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Which blood pressure medication is known to potentially reduce bone loss and hip fracture risk?

  1. Amlodipine

  2. Hydrochlorothiazide

  3. Lisinopril

  4. Losartan

The correct answer is: Hydrochlorothiazide

Hydrochlorothiazide is a thiazide diuretic that has shown potential benefits beyond blood pressure control, particularly regarding bone health. Research indicates that thiazide diuretics can help retain calcium in the body, which may contribute to maintaining bone density. This mechanism can be significant in reducing the risk of osteoporosis and subsequently lowering the incidence of hip fractures in older adults. Regular use of hydrochlorothiazide has been linked to a beneficial effect on bone metabolism, making it a preferred choice for hypertensive patients who may also be at risk for bone loss. Its ability to prevent calcium loss through the kidneys helps in preserving bone integrity over time. While the other medications listed may serve important functions in managing hypertension or other aspects of cardiovascular health, they do not exhibit the same potential to positively influence bone density or fracture risk as hydrochlorothiazide.